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How to Prevent Fluid Retention during BioTropin® HGH Therapy

by Ryan McTeigue on July 13, 2023
Fluid retention is a common side effect of growth hormone (GH) replacement. This aspect of HGH therapy had been known to cause discomfort among end users as fluid accumulation often leads to bloating, painful joints, carpal tunnel syndrome, and a less desirable aesthetic,
But do you know that you can prevent this by taking simple steps during your BioTropin® HGH cycle? Read on so you can enjoy the benefits of BioTropin® HGH without having to deal with the nuisance of the above symptoms.
J. Møller et al had gathered some evidence in their study suggesting that most adults who have sub-optimal HGH levels are also dehydrated. This means that you have low total body water due to decreased intracellular water or plasma volume. When individuals receive HGH replacement, it asserts its anti-natriuretic (salt-saving) and anti-diuretic (water-saving) effects until the body gets properly hydrated, and the fluid compartments return to normal.
Below is a clear illustration of the distribution of fluids in our body.


According to research, as little as 1% dehydration can negatively affect a person’s mood, attention, memory and motor coordination. You don’t have to feel thirsty before you can say you’re dehydrated. By the time you’re craving for that glass of water, your body is already dehydrated; the thirst mechanism falls way behind our actual level of hydration.

As your total body water drops without proper replacement, your blood becomes more concentrated. This is called ‘hemoconcentration’, which then triggers a cascade of hormones namely aldosterone and vasopressin (ADH) to act on your kidneys in order to hold on to water and electrolytes (mainly sodium). And how osmosis works, "where sodium is, water follows."

The result? You become thirsty so you drink more, but you urinate less. 

HGH’s specific mechanism is still unknown but one study showed its direct action on the kidneys. Data suggest that the sodium- and water-retaining effects of HGH are exerted primarily at the level of the distal renal tubules. Consequently, these actions of GH could be mediated via IGF-I. This causes sodium to be reabsorbed in the body, instead of being excreted in the urine. Another research suggests that HGH suppresses the action of ANP (Atrial Natriuretic Peptide), a hormone that antagonizes salt and water retention.



So then, if one starts to drink more water, why do you still experience edema? The answer is simple: Your body needs time to adjust.

The hormones that were secreted by the body to hold on to water and sodium at the time when it’s dehydrated are still in circulation carrying out their effects. Not to mention, the presence of BioTropin® HGH further potentates their fluid-retaining actions.  But as one properly hydrates, fluid homeostasis is restored. The increase in extra cellular fluid (ECF) will then be detected by the receptors of the body, signalling it to stop secreting aldosterone and vasopressin (ADH). This can span for days to weeks. I would suggest to be patient and keep hydrating. You will eventually lose the excess fluid.
Furthermore, Møller explained that the ability of growth hormone to retain fluid should thus be viewed as a beneficial physiological adjustment of fluid balance rather than a negative side effect.
To ensure you are drinking enough fluids, remember this formula to calculate the minimum amount of fluid intake you need within a 24- hour period.

Weight (kg) x 0.033 = Fluid intake in Liters
So for example, an 85 kg man will need to consume at least 2.8 Liters a day. More, if he is physically active, or lives in a warmer climate to account for extra fluid loss due to sweating and evaporation through the skin.

Now, if you have sufficient fluid intake, and still experience fluid retention, check if you are taking the right dose of your BioTropin® HGH. Check with our FAQs section for recommended doses according to gender, age, lifestyle goal, and fitness level.
Lastly, divide your HGH daily dose into 2-3 injections; this will help in decreasing the disrupted balance between the ANP (Atrial Natriuretic Peptide), aldosterone, and vasopressin.